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PALMO (Platform for Analyzing Longitudinal Multi-omics data) is a platform for anayzing longitudinal data from bulk as well as single cell. It allows to identify inter-, intra-donor variations in genes over longitudinal time points. The analysis can be done on bulk expression dataset without known celltype information or single cell with celltype/user-defined groups. It allows to infer stable and variable features in given donor and each celltype (or user defined group). The outlier analysis can be performed to identify technical/biological perturbed samples in donor/participant. Further, differential analysis can be performed to decipher time-wise changes in gene expression in a celltype.